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Psycholing/ Compling Seminar: Lindy Comstock (Dept. of Neurosurgery)- Developing the auditory oddball paradigm as a tool for language mapping

May 19 @ 4:00 pm - 6:00 pm

Successful language development after cerebral hemispherectomy is a vital concern for the well-being of children affected by intractable seizure disorders. Yet, this area of research is underrepresented in the literature, with only a handful of neuroimaging studies devoted to the reorganization of language areas after hemispherectomy. The goal of this project is to provide clinicians with a measure of neural connectivity to assess which pediatric hemispherectomy patients will ultimately develop language and what language-related impairments may arise. The proposed study will be the first to assess neural reorganization in hemispherectomy patients on the level of the effective and dynamic modular structure of connectivity networks, calculated from cortical source-level EEG. The high-resolution EEG whole-brain analysis will provide both superior temporal and spatial localization of language tasks, which can better reflect the extent of reorganization in pathological brains. Currently, we plan to validate the test-retest validity of our measure in healthy control subjects. In this presentation, I will briefly outline the objectives of the project and some of the relative literature. The main focus will be the development of a specialized oddball auditory paradigm. Discussion of the research design and recommendations are welcome.


May 19
4:00 pm - 6:00 pm
Event Category:


Campbell Hall 2122